Chestnut-based therapeutic preparations are effective remedies for preventing and combating numerous blood vessel conditions , such as varicose veins, thrombosis, varicose ulcers, painful cramps or venous insufficiency. The main active ingredient found in Aesculus hippocastanum extract, aescin, is a mixture of triterpene saponins present in two forms, alpha and beta, which are distinguished by their water solubility. Aescin has anti-edematous, anti-inflammatory and venotonic properties. Its venotonic effect has been shown to be mediated by its sensitizing activity on ion channels in the vessel wall, particularly calcium, leading to an increase in contractility. The glycolic extract of wild chestnut from the Avaron® composition forms a barrier against pathogens and promotes the healing of damaged mucosa.